Overstretching Double-Stranded RNA, Double-Stranded DNA, and RNA-DNA Duplexes

Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules.

Single molecules of double-stranded DNA (dsDNA) were stretched with force-measuring laser tweezers. Under a longitudinal stress of approximately 65 piconewtons (pN), dsDNA molecules in aqueous buffer undergo a highly cooperative transition into a stable form with 5.8 angstroms rise per base pair, that is, 70% longer than B form dsDNA. When the stress was relaxed below 65 pN, the molecules rapid...

Double-stranded RNA under force and torque: similarities to and striking differences from double-stranded DNA.

RNA plays myriad roles in the transmission and regulation of genetic information that are fundamentally constrained by its mechanical properties, including the elasticity and conformational transitions of the double-stranded (dsRNA) form. Although double-stranded DNA (dsDNA) mechanics have been dissected with exquisite precision, much less is known about dsRNA. Here we present a comprehensive c...

Double-stranded RNA poses puzzle.

Microglia Recognize Double-Stranded RNA

double-stranded rna viral infection in tehran trichomonas vaginalis isolates.

background : trichomonas vaginalis is a pathogenic protozoon and may be contaminated with dsrna virus called trichomonas vaginalis virus (tvv). the viral infection is an important factor for its patho-genesis and sensitivity to metronidazole. the presence of tvv is associated with qualitative and quantitative expression of cysteine proteinases and surface immunogenic; p270. the purpose of this ...